منابع مشابه
Pathophysiology of Status Epilepticus
Status epilepticus is refractory to initial intravenous anticonvulsants in every third patient and at least the generalised convulsive form is commonly associated with neuronal long-term consequences. The understanding of pathophysiological mechanisms underlying development and maintenance of status epilepticus and its sequelae is therefore of uttermost importance. Spontaneous seizure terminati...
متن کاملStatus epilepticus: pathophysiology and management in adults.
As in Clark and Prout's classic work, we identify three phases of generalised convulsive status epilepticus, which we call impending, established, and subtle. We review physiological and subcellular changes that might play a part in the transition from single seizures to status epilepticus and in the development of time-dependent pharmacoresistance. We review the principles underlying the treat...
متن کاملMicroRNAs in the pathophysiology and treatment of status epilepticus
MicroRNA (miRNA) are an important class of non-coding RNA which function as post-transcriptional regulators of gene expression in cells, repressing and fine-tuning protein output. Prolonged seizures (status epilepticus, SE) can cause damage to brain regions such as the hippocampus and result in cognitive deficits and the pathogenesis of epilepsy. Emerging work in animal models has found that SE...
متن کاملStatus epilepticus and refractory status epilepticus management.
Status epilepticus (SE) describes persistent or recurring seizures without a return to baseline mental status and is a common neurologic emergency. SE can occur in the context of epilepsy or may be symptomatic of a wide range of underlying etiologies. The clinician's aim is to rapidly institute care that simultaneously stabilizes the patient medically, identifies and manages any precipitant con...
متن کاملStatus epilepticus.
PURPOSE OF REVIEW This review presents the state of the art in the diagnosis and management of status epilepticus. RECENT FINDINGS In addition to general background, this article presents the most recent findings regarding the diagnosis and treatment of status epilepticus, including the results of the Rapid Anticonvulsant Medication Prior to Arrival Trial (RAMPART) and the available data on t...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2018
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2016.12.044